BPC-157 + TB-500

BPC-157 and TB-500 represent the two primary pillars of research-based peptide therapy for wound repair. BPC-157 is a stable gastric pentadecapeptide that offers deep cytoprotection and accelerates the healing of the Extracellular Matrix (ECM). TB-500 is a segment of the Thymosin Beta-4 protein that acts as a systemic repair signal, particularly in muscle and skin tissue. Their synergy is found in the way they manage actin—the fundamental protein of cellular movement—and their ability to upregulate the body's natural growth factors, creating an environment where tissue repair is both faster and more structurally sound.

Product Structure

These high-purity peptides are synthesized to match exact biological benchmarks for research purposes.

BPC-157 Composition:

Carbon 62, Hydrogen 98, Nitrogen 16, Oxygen 22

Plain Text Sequence: Gly-Pro-Leu-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

TB-500 Composition:

Carbon 212, Hydrogen 350, Nitrogen 56, Oxygen 78, Sulfur 1

Plain Text Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser

Research

The Dynamic Role of Actin in Cell Migration

For a wound to heal, repair cells like fibroblasts must move from healthy tissue into the damaged zone. This migration is powered by the assembly and disassembly of actin filaments.

• BPC-157 Synergy: It works at the genetic level to boost the overall production of actin, ensuring the cell has an abundant supply of the necessary proteins.
• TB-500 Synergy: It binds to actin monomers (G-actin) and carries them to the cell membrane to form long filaments (F-actin). This process creates the "tracks" that allow the cell to move forward.
  Together, these peptides ensure that cells are not only healthy but are also highly mobile, allowing them to reach the injury site in a fraction of the time usually required by the body.

Growth Hormone and Metabolic Efficiency

BPC-157 has been shown to increase the presence of Growth Hormone (GH) receptors on tendon fibroblasts. This upregulation allows the cells to survive longer and work more effectively in the reconstruction of soft tissue. When TB-500 is present, the metabolic demand of this increased activity is supported by better cellular structure and increased nutrient delivery through improved blood flow.

Key Regenerative Metrics

Benefit Area

BPC-157 Primary Effect

TB-500 Primary Effect

Cumulative Result

Cell Movement

Increased actin production

Directed actin assembly

Faster wound closing

Tissue Strength

Improved collagen layout

Enhanced fiber flexibility

More resilient scars

Blood Flow

Early-stage angiogenesis

Endothelial cell transit

Superior oxygenation

Cell Survival

Increased GH sensitivity

Anti-apoptotic signaling

Prolonged repair phase

Storage

Store lyophilized vials in a freezer at -20 degrees Celsius for maximum shelf life. Avoid light exposure. Once reconstituted with bacteriostatic water, the peptide solution must be refrigerated between 2 and 8 degrees Celsius. Reconstituted peptides should be used within 30 days. Do not shake the vial as it may break the delicate peptide bonds; instead, gently swirl to mix.

About The Author

The literature presented above was investigated, reviewed and compiled by Dr. E. Logan, M.D. Dr. E. Logan earned a doctoral qualification from Case Western Reserve University School of Medicine along with a B.S. in molecular biology.

Scientific Journal Author

Dr. Allen L. Goldstein, MD, is the Catherine B. and William McCormick Chair in the department of Biochemistry and Molecular Biology at George Washington University. As the researcher who originally identified and characterized Thymosin Beta-4, he has published over 400 papers and holds 15 patents. He is a member of the Board of Trustees of the Albert Sabin Vaccine Institute and Vice Chairman of BioPeptide Corporation. His inclusion here is for scientific attribution and does not imply a commercial endorsement.

Resources

C.-H. Chang, W.-C. Tsai, M.-S. Lin, Y.-H. Hsu, and J.-H. S. Pang, "How pentadecapeptide BPC 157 affects tendon healing through the participation of tendon outgrowth, cellular viability, and cellular movement," J. Appl. Physiol., vol. 110, no. 3, pp. 774-780, Oct. [Physiology.org]

J. Kim and Y. Jung, "The Influence of Thymosin Beta 4 in Hepatic Fibrosis," Int. J. Mol. Sci., vol. 16, no. 5, pp. 10624-10635, May 2015. [NCBI]

C.-H. Chang, W.-C. Tsai, Y.-H. Hsu, and J.-H. S. Pang, "How pentadecapeptide BPC 157 amplifies growth hormone receptor presence in fibroblast cells of tendons," Mol. Biol. Switz., vol. 19, no. 5, pp. 19066-19077, Nov. 2014. [NCBI]

Sean, Bao and Chu, Hsun and Yenn, Huang and Xi, Xiao, Mauro and Park, Yong-Beum Kim, Kyoung. (2012). Relationship between thyroid hormone concentrations in patients with rheumatic conditions and their inflammatory markers and therapeutic response. Clinical rheumatology. 31. 1253-8. 10.1007/s10067-012-2011-7. [Research Gate]

Philp, D., et al. "The Role of Thymosin Beta 4 in Tissue Regeneration, Injury Recovery, and Follicular Growth." "Age-Related Changes and Development," vol. 125, no. 2, Feb. 2010, pp. 113-119. [PubMed.gov]